Interesting Cases

A clinical log for optometrists and eye care professionals.

Cases are drawn from NHS and private medical retina practice in Brighton, covering a range of conditions encountered in routine optometry referrals and emergency eye care. Each case includes OCT interpretation, differential diagnosis and management.

Filter by topic: acquired vitelliform lesion acute macular neuroretinopathy aflibercept AION AMD AMD differential AMN anti-VEGF aripiprazole asymptomatic bilateral branch retinal vein occlusion BRVO butterfly-shaped pattern dystrophy cataract central retinal artery occlusion central serous chorioretinopathy chorioretinopathy choroid choroidal haemangioma choroidal lesion choroidal macrovessel choroidal melanoma choroidal neovascularisation cilioretinal artery CNVM co-management congenital CRAO CSCR diabetic retinopathy dominant drusen Doyne honeycomb retinal dystrophy drug toxicity drug-related early onset EFEMP1 ellipsoid zone endovascular epiretinal membrane ERM Eylea FCE FFA focal choroidal excavation fovea haemorrhage hydroxychloroquine ICG incidental finding infrared imaging inherited macular dystrophy inner nuclear layer ischaemia ischaemic optic neuropathy lupus macular degeneration macular hole macular oedema maculopathy microcystic macular oedema multimodal imaging near-infrared negative scotoma NVE OCT OCT angiography optic neuropathy optometrist referral outer retina pachychoroid pachychoroid neovasculopathy PAMM panretinal photocoagulation paracentral scotoma paraophthalmic aneurysm pattern dystrophy PDT PED peripapillary pigment epithelial detachment PNV post-operative posterior vitreous detachment proliferative PVD referral retinal tear retinal vein occlusion RPE screening serial imaging Stargardt sub-ILM subretinal fluid torpedo maculopathy type 1 CNV Valsalva virtual clinic vitelliform vitrectomy vitreoretinal vitreous haemorrhage
torpedo maculopathy congenital

Two incidental findings, one routine sight test

A 64-year-old woman is referred with an abnormal right macular OCT. The findings are diagnostic of torpedo maculopathy - a rare congenital RPE anomaly. An incidental longstanding peripheral retinal tear is also identified in the left eye, requiring no treatment.

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pattern dystrophy butterfly-shaped pattern dystrophy

A vitelliform-like lesion and the pattern that gives it away

A 77-year-old woman is referred with a vitelliform-like left macular lesion on OCT. Near-infrared fundus imaging of both eyes reveals a characteristic cruciform pigment pattern - diagnostic of butterfly-shaped pattern dystrophy, and a reminder that the image beside the OCT is sometimes the most important one.

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BRVO branch retinal vein occlusion

A vitelliform lesion with a vascular clue

An 87-year-old woman is referred urgently with a working diagnosis of vitelliform macular dystrophy and dot and blot haemorrhages. OCT and careful fundus interpretation point instead to a single unifying diagnosis: an old superotemporal BRVO with secondary ERM and an acquired vitelliform lesion at the fovea.

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choroidal haemangioma choroidal melanoma

A growing choroidal lesion: the importance of serial imaging

A 57-year-old woman is referred with a growing left macular lesion and a hypermetropic shift in visual acuity. Serial OCT demonstrates interval growth of a choroidal lesion with an overlying serous PED, raising a broad differential that includes circumscribed choroidal haemangioma, CSCR spectrum disease, and choroidal melanoma.

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choroidal macrovessel choroid

Choroidal macrovessel presenting as an incidental OCT abnormality

A 52-year-old asymptomatic man is referred after his first macular OCT reveals a raised area temporal to the fovea. The imaging is typical of a choroidal macrovessel - a benign anomalous dilated choroidal vessel that can mimic more sinister pathology. Confident remote interpretation allowed reassurance without a hospital visit.

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aripiprazole chorioretinopathy

Aripiprazole-associated chorioretinopathy with bilateral subretinal fluid

A 43-year-old man with schizophrenia on long-term aripiprazole presents with bilateral subretinal fluid presumed to be CSCR. Drug history reveals a recognised but rare antipsychotic association, and a complex risk-benefit discussion with his psychiatrist determines that medication cannot be withdrawn.

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macular hole vitrectomy

Full-thickness macular hole with reassuring fellow eye OCT

A 64-year-old woman is found to have a right full-thickness macular hole at a routine sight test, with no preceding visual symptoms. Bilateral OCT confirms the diagnosis and reveals a left posterior vitreous detachment - reassuring for the fellow eye and a prompt for direct referral to the vitreoretinal team.

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CRAO central retinal artery occlusion

Loss of vision after an elective procedure

A 40-year-old woman wakes from elective endovascular coiling of a paraophthalmic ICA aneurysm with no perception of light in the left eye. Serial OCT over three months illustrates the acute and chronic phases of central retinal artery occlusion, with apparent cilioretinal artery sparing but NPL vision raising the possibility of concurrent ischaemic optic neuropathy.

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EFEMP1 dominant drusen

When the age doesn't fit the diagnosis

A 57-year-old man is referred having carried a diagnosis of early-onset dry AMD since his late thirties. The age of onset alone is enough to question the label - and the imaging raises a broad differential including dominant drusen, pachychoroid drusen, and inherited macular dystrophy.

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pachychoroid neovasculopathy PNV

When CSCR becomes something more: a multimodal imaging case

A 57-year-old man with longstanding CSCR and 18 prior bevacizumab injections is reviewed with ongoing disease activity. Multimodal imaging including FFA, ICG, OCT angiography and structural OCT confirms pachychoroid neovasculopathy - a distinct entity within the pachychoroid spectrum - and guides a switch to aflibercept with good treatment response.

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drug toxicity hydroxychloroquine

Asymptomatic hydroxychloroquine retinopathy

A 60-year-old woman on long-term hydroxychloroquine for lupus is found to have bilateral parafoveal outer retinal loss on routine OCT — a reminder of the importance of screening guidelines.

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